diastolic dysfunction
Impaired relaxation and filling of the heart during diastole, often leading to heart failure with preserved ejection fraction.
Full Definition
Diastolic dysfunction refers to abnormal left ventricular relaxation, filling, or distensibility that can occur with preserved or reduced ejection fraction. This condition is characterized by elevated filling pressures and reduced compliance of the left ventricle. Diastolic dysfunction is graded from I to III based on echocardiographic parameters including E/A ratio, deceleration time, and tissue Doppler measurements. It represents the underlying mechanism for heart failure with preserved ejection fraction (HFpEF) and is commonly associated with hypertension, aging, and diabetes.
Usage
Usage note: Should be graded when identified and distinguished from systolic dysfunction.
In Context
- "Echocardiography demonstrated Grade II diastolic dysfunction with elevated filling pressures." — Cardiology consultation
- "The patient's heart failure symptoms were attributed to severe diastolic dysfunction despite preserved LVEF." — Clinical assessment