MACE
Also written as: MACE — Major Adverse Cardiac Events
Composite endpoint used in cardiovascular research encompassing major adverse cardiac events including death, myocardial infarction, and revascularization.
Full Definition
Major Adverse Cardiac Events (MACE) is a standardized composite endpoint commonly used in cardiovascular clinical trials and outcome studies. The typical components include cardiovascular death, non-fatal myocardial infarction, and target vessel revascularization, though specific definitions may vary between studies. MACE serves as a clinically meaningful measure of treatment efficacy and patient outcomes in cardiovascular imaging studies, particularly when assessing the prognostic value of various imaging modalities or the impact of therapeutic interventions.
Usage
Usage note: Always specify which events are included in the MACE definition, as components can vary between studies.
In Context
- "The study's primary endpoint was MACE at 12 months following stress testing." — Research protocol
- "Patients with abnormal stress imaging had a significantly higher incidence of MACE during follow-up." — Clinical outcomes study