CIMT progression rate
Annual change in carotid intima-media thickness measured by ultrasound. Used as surrogate endpoint for atherosclerosis progression in prevention studies.
Full Definition
CIMT progression rate refers to the annual change in carotid intima-media thickness measured by high-resolution ultrasound, typically expressed in micrometers per year. This non-invasive measure serves as a validated surrogate endpoint for atherosclerosis progression in cardiovascular prevention research. Normal progression rates are generally <10-20 μm/year, while accelerated progression (>40 μm/year) suggests active atherosclerotic disease. CIMT progression correlates with cardiovascular events and responds to lipid-lowering interventions, making it valuable for monitoring treatment efficacy in prevention trials.
Usage
Usage note: Express in micrometers per year; distinguish from absolute CIMT values.
In Context
- "The intervention group demonstrated significantly reduced CIMT progression rate compared to placebo over 24 months." — Clinical trial report
- "CIMT progression rate serves as a validated surrogate endpoint for cardiovascular prevention studies." — Research methodology paper