COURAGE trial
Also written as: COURAGE — Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation
Landmark randomized trial comparing percutaneous coronary intervention plus optimal medical therapy versus optimal medical therapy alone in stable coronary disease.
Full Definition
The COURAGE trial was a pivotal randomized controlled trial that compared percutaneous coronary intervention (PCI) plus optimal medical therapy with optimal medical therapy alone in patients with stable coronary artery disease. Published in 2007, the trial demonstrated that PCI did not reduce death or myocardial infarction compared to optimal medical therapy alone, fundamentally changing the approach to stable coronary disease management. The trial emphasized the importance of aggressive medical management including lipid-lowering therapy, antiplatelet agents, and blood pressure control. COURAGE established optimal medical therapy as the preferred initial strategy for most patients with stable coronary disease.
Usage
Usage note: Capitalize as proper noun; landmark study frequently referenced in prevention literature.
In Context
- "The COURAGE trial results support optimal medical therapy as first-line treatment for stable coronary artery disease." — Clinical guideline reference
- "Post-COURAGE era management emphasizes intensive cardiovascular prevention before considering revascularization in stable patients." — Medical education material