JUPITER trial
Pronunciation: JOO-pi-ter
Also written as: JUPITER — Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin
Pivotal study demonstrating statin benefits in patients with normal LDL but elevated hs-CRP.
Full Definition
The Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) was a landmark randomized controlled trial that expanded the evidence base for statin therapy. The study enrolled patients with LDL cholesterol below 130 mg/dL but elevated high-sensitivity C-reactive protein (≥2.0 mg/L), demonstrating a 44% reduction in major cardiovascular events with rosuvastatin. JUPITER was terminated early due to clear benefit and led to updated guidelines recommending statins for primary prevention in patients with elevated inflammatory markers.
Usage
Usage note: Capitalize all letters; refers to the specific clinical trial
In Context
- "The JUPITER trial expanded statin indications to include patients with normal LDL but elevated inflammatory markers." — Guideline development document
- "Post-JUPITER trial analyses have examined the role of hs-CRP in cardiovascular risk stratification." — Meta-analysis publication