PCSK9
Pronunciation: P-C-S-K-nine
Also written as: PCSK9 — proprotein convertase subtilisin/kexin type 9
Protein enzyme that regulates LDL receptor degradation and cholesterol metabolism.
Full Definition
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that plays a crucial role in cholesterol homeostasis by promoting degradation of LDL receptors in hepatocytes. When PCSK9 binds to LDL receptors, it prevents their recycling to the cell surface, leading to increased circulating LDL cholesterol levels. Understanding PCSK9 function led to development of PCSK9 inhibitor medications (monoclonal antibodies and siRNA therapies) that dramatically lower LDL cholesterol by blocking this protein's action.
Usage
Usage note: No spaces or hyphens; distinguish from PCSK9 inhibitor drugs
In Context
- "Genetic variants in PCSK9 are associated with lifelong differences in LDL cholesterol levels." — Genetic research paper
- "The discovery of PCSK9's role in cholesterol metabolism revolutionized lipid-lowering therapy development." — Pharmacology review article