plaque regression
The reduction in size or density of atherosclerotic plaques through therapeutic intervention.
Full Definition
Plaque regression refers to the measurable reduction in atherosclerotic plaque volume, density, or composition achieved through aggressive lipid-lowering therapy or other interventions. This process can be monitored through imaging techniques such as intravascular ultrasound (IVUS) or coronary CT angiography. Clinical studies have demonstrated that intensive statin therapy can lead to plaque regression, which correlates with reduced cardiovascular events. The concept is important in cardiovascular prevention as it represents actual reversal of disease rather than just stabilization.
Usage
Usage note: Distinguish from plaque stabilization, which refers to making plaques less prone to rupture rather than reducing their size.
In Context
- "The study demonstrated significant plaque regression in patients receiving high-intensity statin therapy over 24 months." — Clinical research report
- "IVUS imaging confirmed plaque regression with a 15% reduction in total atheroma volume." — Cardiology consultation note