STOP-HTN
Also written as: STOP-HTN — Swedish Trial in Old Patients with Hypertension
Swedish Trial in Old Patients with Hypertension; landmark study establishing antihypertensive therapy benefits in elderly patients.
Full Definition
The Swedish Trial in Old Patients with Hypertension (STOP-HTN) was a pioneering randomized controlled trial that demonstrated the cardiovascular benefits of antihypertensive treatment in elderly patients aged 70-84 years. The study showed significant reductions in stroke, myocardial infarction, and cardiovascular mortality with beta-blocker and diuretic therapy compared to placebo. STOP-HTN was crucial in establishing that blood pressure treatment benefits extend to elderly populations, influencing guidelines that previously recommended less aggressive treatment in older adults. The trial helped define modern approaches to hypertension management across all age groups.
Usage
Usage note: Important historical trial; distinguish from other major hypertension studies.
In Context
- "STOP-HTN established the foundation for treating hypertension in elderly patients with significant cardiovascular benefits." — Historical review of hypertension trials
- "The landmark findings of STOP-HTN influenced current guidelines recommending blood pressure targets regardless of age." — Clinical guideline development