late lumen loss
Quantitative angiographic measurement of luminal renarrowing from post-procedure to follow-up angiography.
Full Definition
Late lumen loss (LLL) is a quantitative angiographic endpoint that measures the difference between the minimal lumen diameter immediately after percutaneous coronary intervention and the minimal lumen diameter at follow-up angiography, typically 6-9 months later. LLL reflects the degree of neointimal hyperplasia and vessel remodeling that occurs after stent implantation or balloon angioplasty. It is expressed in millimeters, with lower values indicating better long-term vessel patency. LLL is a primary surrogate endpoint in many device trials as it correlates with clinical outcomes including target lesion revascularization rates.
Usage
Usage note: Hyphenate 'late lumen loss'; express measurements in millimeters with appropriate precision.
In Context
- "The drug-eluting stent demonstrated significantly lower late lumen loss compared to bare metal stent at 9-month follow-up." — Clinical trial results
- "Late lumen loss of 0.15 mm indicated excellent neointimal suppression with the new stent platform." — Angiographic analysis