MACE
Also written as: MACE — Major Adverse Cardiac Events
Composite endpoint used in cardiovascular trials encompassing death, myocardial infarction, and revascularization.
Full Definition
Major Adverse Cardiac Events (MACE) is a standardized composite endpoint used in cardiovascular research and clinical trials to assess the efficacy of treatments. It typically includes cardiovascular death, non-fatal myocardial infarction, and target vessel revascularization. The specific components of MACE can vary between studies, making careful attention to definitions essential for editorial accuracy. Some studies may include stroke or hospitalization for heart failure as additional components.
Usage
Usage note: Always specify which components are included in MACE for a particular study, as definitions vary.
In Context
- "The 30-day MACE rate was significantly lower in the drug-eluting stent group compared to bare metal stents." — Clinical trial report
- "MACE definition varied across studies, with some including target lesion revascularization while others used target vessel revascularization." — Meta-analysis