PANDAS
Also written as: PANDAS — Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, causing sudden onset of OCD or tics.
Full Definition
PANDAS refers to a subset of children who develop obsessive-compulsive disorder (OCD) and/or tic disorders following group A streptococcal infections. The condition is characterized by an abrupt onset or dramatic worsening of symptoms, typically occurring between ages 3 and puberty. Children may also exhibit behavioral regression, emotional lability, and attention difficulties. The proposed mechanism involves molecular mimicry, where antibodies targeting streptococcal bacteria cross-react with brain tissue. Diagnosis remains controversial, and treatment may include antibiotics, immunomodulatory therapies, and standard psychiatric interventions.
Usage
Usage note: Spell out full form on first mention in formal documents.
In Context
- "The differential diagnosis considered PANDAS given the temporal relationship between strep throat and symptom onset." — Clinical notes
- "PANDAS remains a controversial diagnosis requiring careful evaluation of symptom timeline and infectious triggers." — Case presentation