ACTH
Pronunciation: A-C-T-H
Also written as: ACTH — adrenocorticotropic hormone
Adrenocorticotropic hormone, a first-line treatment for infantile epileptic spasms syndrome.
Full Definition
ACTH (adrenocorticotropic hormone) is a peptide hormone and gold-standard treatment for infantile epileptic spasms syndrome. The mechanism of action in treating spasms is not fully understood but likely involves both direct effects on brain corticotropin receptors and indirect effects through stimulation of adrenal corticosteroid production. ACTH is typically administered as intramuscular injections over several weeks, with careful monitoring for side effects including hypertension, hyperglycemia, and increased infection risk. Response rates are generally higher with ACTH compared to oral corticosteroids, making it the preferred first-line therapy despite its significant side effect profile.
Usage
Usage note: Always use capitals. Distinguish from ADHD (attention deficit hyperactivity disorder).
In Context
- "The patient showed complete cessation of spasms after two weeks of ACTH therapy." — Progress note
- "ACTH remains the gold standard treatment for cryptogenic infantile epileptic spasms syndrome." — Treatment protocol