Professional
Technical
IVT
agyria
Pronunciation: ah-JYE-ree-ah
Complete absence of cerebral gyri, resulting in a smooth brain surface.
Full Definition
A severe form of lissencephaly characterized by the complete absence of cerebral gyri and sulci, resulting in a smooth brain surface. This malformation occurs during early brain development and is associated with severe developmental delays, seizures, and shortened life expectancy. The condition is typically diagnosed through neuroimaging and may be caused by genetic mutations affecting neuronal migration.
Usage
Usage note: Often hyphenated when used with pachygyria (agyria-pachygyria complex).
In Context
- "The MRI revealed agyria with complete absence of cortical folding." — Radiology report
- "Genetic testing confirmed a mutation associated with agyria-pachygyria complex." — Clinical genetics consultation
Also known as
smooth brain
complete lissencephaly
Contrasted with
polymicrogyria
pachygyria
Don't confuse with
pachygyria
polymicrogyria