Lennox-Gastaut syndrome
Pronunciation: LEN-ox GAS-toh
Severe childhood epilepsy syndrome characterized by multiple seizure types, intellectual disability, and distinctive EEG pattern.
Full Definition
Lennox-Gastaut syndrome (LGS) is a severe form of childhood-onset epilepsy characterized by a triad of features: multiple seizure types (including tonic, atonic, and atypical absence seizures), intellectual disability or developmental delay, and a distinctive interictal EEG pattern showing slow spike-and-wave complexes. The syndrome typically begins between ages 2-8 years and is often medication-resistant. Patients frequently experience drop attacks that can cause injuries from falls. The prognosis is generally poor, with most patients requiring lifelong care. Treatment is challenging and may include multiple antiepileptic drugs, ketogenic diet, or surgical interventions like corpus callosotomy.
Usage
Usage note: Often abbreviated as LGS; emphasize the syndrome's severity and poor prognosis.
In Context
- "The combination of drop attacks and slow spike-wave on EEG confirmed Lennox-Gastaut syndrome." — Epilepsy diagnosis
- "Management of Lennox-Gastaut syndrome required a multimodal approach including medication and dietary therapy." — Treatment planning