Professional
Technical
IVT
neuronal migration disorder
Congenital brain malformations caused by abnormal movement of neurons during fetal brain development.
Full Definition
Neuronal migration disorders result from disrupted neuronal migration during cortical development, typically occurring between 12-24 weeks of gestation. These disorders create abnormal brain architecture that often manifests as developmental delays, intellectual disability, and epilepsy. Common types include schizencephaly, heterotopias, and various forms of cortical dysplasia. Diagnosis is made through specialized brain imaging, and treatment focuses on managing seizures and developmental support.
Usage
Usage note: Often abbreviated as NMD in clinical notes; specify subtype when known.
In Context
- "MRI findings were consistent with a neuronal migration disorder affecting the left hemisphere." — Radiology report
- "The child's refractory epilepsy was attributed to an underlying neuronal migration disorder." — Pediatric neurology consultation
Also known as
cortical migration disorder
Don't confuse with
neuronal proliferation disorder
cortical dysplasia