Intermediate
Technical
IVT
Pharmacoresistant Epilepsy
Epilepsy that fails to become seizure-free despite adequate trials of two appropriately chosen antiepileptic drugs.
Full Definition
Pharmacoresistant epilepsy, also known as drug-resistant epilepsy, is defined by the International League Against Epilepsy as failure to achieve sustained seizure freedom despite adequate trials of two appropriately chosen and tolerated antiepileptic drug schedules. This definition helps clinicians identify patients who may benefit from alternative treatments such as epilepsy surgery, vagus nerve stimulation, or dietary therapy. The term has largely replaced 'refractory epilepsy' in modern clinical practice.
Usage
Usage note: Preferred over 'refractory' in contemporary medical writing.
In Context
- "The child was diagnosed with pharmacoresistant epilepsy after failing multiple antiepileptic drug trials." — Medical record
- "Surgical evaluation is recommended for patients with pharmacoresistant epilepsy." — Treatment guideline
Also known as
drug-resistant epilepsy
medically refractory epilepsy
Contrasted with
drug-responsive epilepsy
controlled epilepsy
Don't confuse with
refractory epilepsy
intractable epilepsy