Professional
Technical
IVT
polymicrogyria
Pronunciation: pol-ee-my-kroe-JYE-ree-ah
Brain malformation with excessive small, abnormally folded gyri creating a bumpy cortical surface.
Full Definition
A cortical malformation characterized by an excessive number of abnormally small gyri that are irregularly folded, creating a characteristic bumpy or cobblestone appearance on brain imaging. This condition results from abnormal late neuronal migration or early cortical organization during fetal development. Polymicrogyria can be focal or diffuse, unilateral or bilateral, and often presents with seizures, developmental delays, and neurological deficits depending on the location and extent of involvement. The condition may be associated with genetic mutations or prenatal insults such as infection.
In Context
- "High-resolution MRI revealed bilateral perisylvian polymicrogyria." — Neuroimaging report
- "The patient's pseudobulbar palsy was attributed to bilateral opercular polymicrogyria." — Pediatric neurology consultation
Also known as
multiple small gyri
cobblestone cortex
Contrasted with
agyria
pachygyria
normal gyral pattern
Don't confuse with
pachygyria
agyria
cortical dysplasia