subependymal giant cell astrocytoma
Also written as: SEGA — subependymal giant cell astrocytoma
A benign brain tumor that develops near the ventricles in patients with tuberous sclerosis complex, requiring surgical monitoring and potential intervention.
Full Definition
Subependymal giant cell astrocytoma (SEGA) is a slow-growing, benign brain tumor that characteristically develops at the foramen of Monro in patients with tuberous sclerosis complex. These tumors arise from subependymal nodules and can cause obstructive hydrocephalus due to their strategic location. While histologically benign, SEGAs require careful monitoring through serial neuroimaging and may necessitate surgical resection or mTOR inhibitor therapy when they demonstrate growth or cause ventricular obstruction. The term is crucial in pediatric neurology documentation as it represents a specific complication of tuberous sclerosis that requires multidisciplinary management.
Usage
Usage note: Always specify the full term on first use in clinical documentation, with SEGA abbreviation acceptable in subsequent references within the same document.
In Context
- "Serial MRI surveillance revealed progressive enlargement of the subependymal giant cell astrocytoma, prompting neurosurgical consultation." — Pediatric neurology consultation note
- "The patient's tuberous sclerosis complex was complicated by a subependymal giant cell astrocytoma requiring everolimus therapy." — Treatment plan documentation