vigabatrin
Pronunciation: vy-GAB-ah-trin
An antiepileptic drug that is first-line treatment for infantile spasms, particularly in tuberous sclerosis complex.
Full Definition
Vigabatrin is a gamma-aminobutyric acid (GABA) transaminase inhibitor that increases brain GABA levels and serves as a crucial antiepileptic drug in pediatric neurology. It is particularly effective as first-line treatment for infantile epileptic spasms associated with tuberous sclerosis complex, where it may be preferred over ACTH. Vigabatrin is also used for focal seizures refractory to other medications. The drug requires careful monitoring due to the risk of irreversible bilateral concentric visual field defects, necessitating regular ophthalmological assessments. Despite this significant side effect, vigabatrin remains essential in treating specific epilepsy syndromes where benefits outweigh risks.
Usage
Usage note: Not to be confused with gabapentin or other GABA-related drugs. Requires specialized visual monitoring.
In Context
- "Vigabatrin was chosen as first-line therapy given the patient's tuberous sclerosis complex." — Treatment plan
- "Regular visual field monitoring is mandatory for all patients receiving vigabatrin." — Clinical protocol