cavernous malformation
Low-flow vascular malformation consisting of dilated, thin-walled vessels that can cause seizures or hemorrhage.
Full Definition
Cavernous malformations, also known as cavernomas or cavernous angiomas, are benign vascular lesions characterized by clusters of abnormally dilated, thin-walled capillaries without intervening normal brain tissue. These lesions have a distinctive 'mulberry' appearance on MRI and carry a risk of bleeding, seizures, and neurological deficits depending on their location. They can be sporadic or familial, with the familial form associated with specific genetic mutations. Treatment decisions depend on factors including bleeding history, seizure control, and lesion accessibility. Editors should note that 'cavernoma' is the preferred shortened form in British English, while 'cavernous malformation' is standard in American medical literature.
Usage
Usage note: Preferred over 'cavernous hemangioma' which is histologically inaccurate.
In Context
- "The cavernous malformation in the temporal lobe was identified as the seizure focus during presurgical evaluation." — Surgical planning report
- "Family screening revealed multiple cavernous malformations consistent with familial cavernomatosis." — Genetic consultation note