kindling
Progressive increase in seizure susceptibility following repeated subthreshold electrical or chemical stimulation of brain tissue.
Full Definition
Kindling is a neurobiological phenomenon discovered in epilepsy research where repeated application of initially subthreshold electrical or chemical stimuli to brain tissue progressively lowers the seizure threshold, eventually resulting in spontaneous seizures. This process involves permanent changes in neural excitability and synaptic plasticity, particularly in the limbic system. The kindling model has provided crucial insights into epileptogenesis and the development of temporal lobe epilepsy. The concept also has implications for understanding how minor repeated brain insults may accumulate to produce significant neurological dysfunction over time.
Usage
Usage note: Use in neurological context to distinguish from psychological/psychiatric kindling.
In Context
- "The kindling phenomenon explains how minor repeated seizures can lead to progressive epileptogenesis." — Research publication
- "Animal models of kindling have been instrumental in developing our understanding of temporal lobe epilepsy mechanisms." — Review article