glycopyrrolate
Pronunciation: gly-koh-PIR-oh-layt
A quaternary anticholinergic drug used as a premedication in dental anesthesiology to reduce secretions and treat intraoperative bradycardia.
Full Definition
Glycopyrrolate is favoured over atropine in many dental anesthesiology protocols because its quaternary ammonium structure prevents passage across the blood-brain barrier, thereby avoiding central nervous system effects such as confusion or restlessness. It reduces salivary, bronchial, and gastric secretions and is also used to reverse bradycardia caused by vagal stimulation. Editors should note the correct spelling—'glycopyrrolate' not 'glycopyrolate'—and verify that dose and route are documented in procedural records. The brand name Robinul is capitalised; the generic form is not.
Usage
Usage note: Common misspelling: 'glycopyrolate' (single 'r'). Always verify in drug-name editing. Generic is lowercase; brand name Robinul is capitalised.
In Context
- "Glycopyrrolate 0.2 mg IV was administered to treat the intraoperative bradycardia before proceeding." — Intraoperative anesthesia record
- "The premedication protocol specified glycopyrrolate as the preferred antisialagogue for patients over 12 years of age." — Office-based dental sedation protocol