Crevicular Fluid
Also written as: GCF — Gingival Crevicular Fluid
The serum-like fluid that seeps from the gingival tissues into the gingival sulcus, used as a diagnostic and research medium.
Full Definition
Gingival crevicular fluid (GCF) is a transudate or exudate found in the gingival sulcus, derived from serum and locally produced by gingival tissues. Its volume and composition change with the degree of periodontal inflammation, making it a valuable biomarker in periodontal research. In healthy tissue, GCF flow is minimal; in diseased tissue, flow increases and cytokines such as interleukin-1β are elevated. Editors encountering this term in periodontal research manuscripts should be alert to its full form, 'gingival crevicular fluid,' and its standard abbreviation, GCF. It should not be confused with 'sulcular fluid,' a near-synonym that some authors use interchangeably.
Usage
Usage note: Spell out 'gingival crevicular fluid' at first mention, followed by '(GCF)'; use the abbreviation thereafter.
In Context
- "Elevated matrix metalloproteinase levels in the crevicular fluid correlated with clinical attachment loss in the study cohort." — Periodontal research article
- "GCF samples were collected using calibrated Periopaper strips prior to any mechanical debridement." — Materials and Methods section