Angioedema
Pronunciation: an-jee-oh-EH-deh-muh
A transient, localised swelling of the deep dermis, subcutaneous tissue, or submucosa caused by increased vascular permeability.
Full Definition
Angioedema involves rapid, self-limiting oedema of the deep dermis and subcutaneous layers, most commonly affecting the face, lips, tongue, throat, and extremities. It may be allergic (IgE-mediated), hereditary (C1-esterase inhibitor deficiency), or drug-induced (particularly by ACE inhibitors). Editors should note it is a distinct entity from urticaria, though both may coexist. The term is often misspelled as 'angio-oedema' (preferred in some British style guides) or confused with plain oedema. In clinical documents it frequently appears alongside anaphylaxis protocols and emergency management sections.
Usage
Usage note: Both 'angioedema' (American) and 'angio-oedema' (British) are acceptable; editors should apply house style consistently within a document.
In Context
- "The discharge summary documented recurrent angioedema of the lips following introduction of lisinopril." — Discharge summary
- "Hereditary angioedema is coded separately from allergic angioedema in the ICD-11 classification." — Coding guidance document