Biologics
A class of large-molecule therapeutic agents derived from biological sources, including monoclonal antibodies targeting cytokines used in inflammatory dermatoses.
Full Definition
In dermatology, biologics (also 'biologicals' in some national style guides) refers to therapeutic proteins—predominantly monoclonal antibodies and fusion proteins—that target specific immune pathway components such as TNF-α, IL-17, IL-23, and IL-4/IL-13. They are used for moderate-to-severe psoriasis, atopic dermatitis, hidradenitis suppurativa, and other inflammatory conditions. Editors should note that 'biologic' functions as both noun and adjective; 'biological' is preferred as the adjective in some British regulatory documents. Trade names and INN (International Nonproprietary Names) should be distinguished carefully: e.g., adalimumab (INN) vs Humira (trade name).
Usage
Usage note: Distinguish 'biologic' (noun/adjective, preferred in US and most international journals) from 'biological' (adjective, preferred in some UK regulatory documents). Always use the INN in clinical and academic writing; trade names may appear in parentheses on first use only.
In Context
- "The patient was commenced on a biologic (secukinumab) after failing two conventional systemic therapies." — Dermatology outpatient letter
- "The author used 'biologic' and 'biological' interchangeably; the editor standardised to 'biologic' per the journal's US English style." — Editorial note