Lentigines
Pronunciation: len-TIJ-in-eez
Benign, flat, pigmented macules resulting from a localised increase in melanocyte number, which — unlike ephelides — do not fade with reduced sun exposure.
Full Definition
Lentigines (singular: lentigo) encompass several clinical subtypes including solar lentigines (age spots, liver spots), simple lentigines, and those occurring in the setting of syndromes such as LEOPARD syndrome and Peutz–Jeghers syndrome. They are characterised histologically by elongation of rete ridges and increased melanocyte density. Editors must distinguish 'lentigines' (plural) from 'lentigos', which is a less preferred plural used in some North American texts. The singular 'lentigo' should be preserved when referring to a single lesion. In oncology manuscripts, lentigo maligna (a subtype of melanoma in situ) must be clearly distinguished from benign lentigines.
Usage
Usage note: Preferred plural is 'lentigines'; 'lentigos' is less favoured. Singular: 'lentigo'. Never conflate with lentigo maligna (a melanoma subtype) in oncology documents.
In Context
- "Multiple lentigines on the lips and buccal mucosa prompted investigation for Peutz–Jeghers syndrome." — Gastroenterology referral letter
- "The editor queried whether 'lentigos' (used by the author) should be changed to 'lentigines'; house style confirmed 'lentigines'." — Journal copyedit