Prurigo Nodularis
Pronunciation: proo-RY-go nod-yoo-LAR-is
A chronic, intensely pruritic dermatosis characterised by firm, hyperkeratotic nodules distributed symmetrically on the extensor surfaces, arising from repeated scratching and picking.
Full Definition
Prurigo nodularis (PN) is a chronic neurodermatological condition defined by multiple, firm, dome-shaped, hyperkeratotic nodules ranging from a few millimetres to over 2 cm, located symmetrically on the extensor limbs, upper back, and abdomen, while sparing the central back ('butterfly sign'). The nodules arise from a cycle of intense pruritus and repeated mechanical trauma (scratching, picking), leading to lichenified, excoriated skin. It is associated with atopic dermatitis, systemic diseases (chronic renal failure, HIV), and psychological comorbidities. Editors should note that 'prurigo nodularis' is italicised in some older texts but is now generally written in roman type in current medical publishing.
Usage
Usage note: The abbreviation 'PN' is acceptable after first expansion in specialist reports but should be avoided in general correspondence due to ambiguity. Write in roman type, not italics, in current editorial practice.
In Context
- "The patient's prurigo nodularis had been refractory to conventional therapy and was referred for consideration of dupilumab." — Secondary care referral letter
- "The case series on prurigo nodularis noted that the term 'nodular prurigo' remains acceptable in British journals." — Systematic review manuscript