Xeroderma
Pronunciation: zeer-oh-DER-mah
Abnormal dryness of the skin, resulting from reduced sebaceous and sweat gland activity or impaired barrier function.
Full Definition
Xeroderma describes a clinical state of pathological skin dryness, distinct from simple environmental dryness, and is associated with conditions such as hypothyroidism, ichthyosis, and atopic dermatitis. Histologically it reflects reduced lipid content of the stratum corneum and impaired water retention. In editorial contexts, xeroderma should not be conflated with xeroderma pigmentosum, a rare DNA-repair disorder sharing only the prefix. Editors should note the preferred British spelling ends in '-a' rather than '-ia'. It commonly appears in dermatology case reports, patient information leaflets, and cosmetic-science manuscripts.
Usage
Usage note: Do not shorten to 'XD' in clinical documents; never conflate with xeroderma pigmentosum (XP).
In Context
- "The patient presented with xeroderma of the lower limbs, worsening during winter months." — Dermatology outpatient clinic letter
- "Editors must distinguish xeroderma from xeroderma pigmentosum in oncology cross-referencing." — Editorial style guide note