sepsis
Pronunciation: SEP-sis
Life-threatening organ dysfunction caused by dysregulated host response to infection. Common complication in emergency surgical patients with intra-abdominal infections.
Full Definition
A systemic inflammatory response syndrome resulting from infection that leads to organ dysfunction and potentially death. In emergency surgery, sepsis commonly arises from intra-abdominal infections such as perforated appendicitis, diverticulitis, or anastomotic leaks. The condition requires immediate recognition and aggressive treatment including source control through surgery, broad-spectrum antibiotics, and hemodynamic support. Sepsis represents a surgical emergency when the infectious source requires operative intervention.
Usage
Usage note: Distinguish from 'septic shock' which implies hemodynamic instability requiring vasopressors.
In Context
- "The patient developed sepsis secondary to perforated diverticulitis requiring emergency surgery." — Admission note
- "Postoperative sepsis was managed with broad-spectrum antibiotics and source control." — Progress note