Pharmacoresistant epilepsy
Epilepsy that fails to become seizure-free despite adequate trials of two tolerated antiseizure medications.
Full Definition
Pharmacoresistant epilepsy, also known as drug-resistant epilepsy, is defined as failure to achieve sustained seizure freedom despite adequate trials of two tolerated, appropriately chosen and used antiseizure medication schedules (whether as monotherapies or in combination). This definition was established by the International League Against Epilepsy (ILAE) to standardize terminology and guide treatment decisions. Patients with pharmacoresistant epilepsy may be candidates for epilepsy surgery, neurostimulation devices, or specialized dietary therapies. The diagnosis has important implications for counseling about prognosis, driving restrictions, and treatment planning.
Usage
Usage note: Use the ILAE definition rather than older, less precise terms like 'intractable epilepsy.'
In Context
- "After failing trials of levetiracetam and carbamazepine, the patient was diagnosed with pharmacoresistant epilepsy." — Epilepsy clinic documentation
- "The epilepsy surgery evaluation revealed that the patient met criteria for pharmacoresistant epilepsy." — Pre-surgical assessment report