Polypharmacy
The use of multiple antiseizure medications simultaneously in epilepsy treatment. Associated with increased risk of drug interactions and side effects.
Full Definition
Polypharmacy in epilepsy refers to the concurrent use of multiple antiseizure medications to achieve seizure control. While monotherapy is generally preferred due to better tolerability and compliance, polypharmacy may be necessary in patients with drug-resistant epilepsy. The approach requires careful consideration of drug interactions, additive side effects, and the potential for improved efficacy through complementary mechanisms of action. Rational polypharmacy involves combining medications with different mechanisms rather than simply adding drugs from the same class.
Usage
Usage note: Distinguish from 'polytherapy' which may include non-pharmacological treatments.
In Context
- "The patient's seizures remained uncontrolled despite polypharmacy with three different antiseizure medications." — Clinical progress note
- "Rational polypharmacy using complementary mechanisms of action may be more effective than random drug combinations." — Treatment guideline