PAPPA
Pronunciation: PAP-ah
Also written as: PAPPA — Pregnancy-Associated Plasma Protein A
Pregnancy-Associated Plasma Protein A - a biomarker used in first trimester screening for chromosomal abnormalities.
Full Definition
Pregnancy-Associated Plasma Protein A (PAPPA) is a large glycoprotein produced by the placenta and measured in maternal serum during first trimester screening. Low levels of PAPPA, particularly when combined with reduced free beta-hCG and increased nuchal translucency, are associated with increased risk of trisomy 21 and other chromosomal abnormalities. PAPPA levels also correlate with placental function and are used to assess risk of pregnancy complications including preeclampsia and intrauterine growth restriction.
Usage
Usage note: Often written in all capitals; specify units as MoM (multiples of median) in results.
In Context
- "The first trimester screen showed low PAPPA at 0.3 MoM with normal free beta-hCG." — Prenatal screening result
- "Combined screening included nuchal translucency, PAPPA, and free beta-hCG measurements." — Genetic counseling note