Lewy body dementia
Neurodegenerative disorder characterized by abnormal protein deposits causing cognitive, motor, and visual symptoms.
Full Definition
Lewy body dementia is a progressive neurodegenerative disorder characterized by the presence of abnormal protein deposits called Lewy bodies in brain cells. The condition includes two related disorders: dementia with Lewy bodies (DLB) and Parkinson's disease dementia. Key features include fluctuating cognition, visual hallucinations, REM sleep behavior disorder, and parkinsonian motor symptoms. Patients may show extreme sensitivity to antipsychotic medications, making careful medication management crucial. The condition is the third most common cause of dementia after Alzheimer's disease and vascular dementia.
Usage
Usage note: Distinguish between dementia with Lewy bodies and Parkinson's disease dementia based on timing of symptoms.
In Context
- "The patient's visual hallucinations and fluctuating alertness were consistent with Lewy body dementia." — neurological assessment
- "Antipsychotic medications should be avoided in Lewy body dementia due to severe sensitivity reactions." — medication safety alert