NMDA receptor antagonist
Also written as: NMDA — N-methyl-D-aspartate receptor antagonist
Type of medication that blocks NMDA receptors to potentially slow cognitive decline in moderate to severe dementia.
Full Definition
NMDA receptor antagonists are medications that work by blocking N-methyl-D-aspartate receptors in the brain, which are involved in learning and memory processes. In dementia, excessive glutamate activity can lead to neuronal damage. By partially blocking these receptors, medications like memantine may help regulate glutamate activity and potentially slow cognitive decline. These drugs are typically prescribed for moderate to severe stages of Alzheimer's disease and may be used alone or in combination with cholinesterase inhibitors.
Usage
Usage note: Memantine is the primary NMDA receptor antagonist used in dementia treatment.
In Context
- "The neurologist added an NMDA receptor antagonist to the patient's existing cholinesterase inhibitor therapy." — consultation note
- "NMDA receptor antagonists may help protect against glutamate-induced neurotoxicity in advanced dementia." — pharmacotherapy review