dose-dense chemotherapy

Full Definition

Dose-dense chemotherapy involves administering chemotherapy cycles at reduced intervals compared to conventional schedules, typically every 2 weeks instead of every 3 weeks, while maintaining the same dose intensity. This approach is based on mathematical models suggesting that shorter intervals between treatments may be more effective at preventing tumor regrowth. Dose-dense regimens require growth factor support to manage increased hematologic toxicity. Studies in gynecologic malignancies have shown improved outcomes for certain tumor types with this intensified approach.

Usage

Usage note: Hyphenate when used as a compound modifier.

In Context

• "The patient was started on dose-dense carboplatin and paclitaxel with growth factor support." — treatment plan
• "Dose-dense protocols require careful monitoring for increased hematologic toxicity." — treatment guideline