hereditary cancer syndrome
Inherited genetic condition that significantly increases the lifetime risk of developing certain cancers.
Full Definition
A hereditary cancer syndrome is a genetic disorder caused by inherited mutations in specific genes that substantially increase an individual's predisposition to developing certain types of cancer. In gynecologic oncology, important syndromes include hereditary breast and ovarian cancer (HBOC) syndrome, Lynch syndrome, and Li-Fraumeni syndrome. These conditions are characterized by earlier age of onset, multiple primary cancers, and specific cancer patterns within families. Identification allows for enhanced screening, prophylactic interventions, and genetic counseling for at-risk family members.
Usage
Usage note: Specify the particular syndrome when known (e.g., Lynch syndrome, HBOC).
In Context
- "Genetic testing confirmed a hereditary cancer syndrome warranting enhanced surveillance." — genetics consultation note
- "Family history suggested a possible hereditary cancer syndrome prompting genetic referral." — risk assessment note