lymphovascular invasion
Also written as: LVI — lymphovascular invasion
Tumor cell penetration into lymphatic or blood vessels, indicating increased metastatic potential.
Full Definition
A histopathologic finding characterized by the presence of tumor cells within lymphatic channels or blood vessels, serving as an important prognostic indicator in head and neck cancers. Lymphovascular invasion suggests the tumor's ability to access systemic circulation and lymphatic drainage, significantly increasing the risk of regional and distant metastases. This finding influences staging, treatment planning, and follow-up protocols. The presence of lymphovascular invasion often prompts more aggressive adjuvant therapy and closer surveillance for recurrence.
Usage
Usage note: LVI is standard abbreviation in pathology reports.
In Context
- "Microscopic examination revealed extensive lymphovascular invasion at the tumor periphery." — Pathology report
- "The presence of lymphovascular invasion upstaged the tumor to pT2." — Staging documentation