FISH analysis
Also written as: FISH — Fluorescence In Situ Hybridization
Fluorescence in situ hybridization test used to detect chromosomal abnormalities in hematologic cancers. Essential for diagnosis and prognosis determination.
Full Definition
Fluorescence in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes to detect specific DNA sequences or chromosomal abnormalities. In hematologic oncology, FISH analysis is crucial for identifying genetic aberrations that guide diagnosis, treatment selection, and prognosis. It can detect deletions, translocations, and amplifications that may not be visible in standard karyotype analysis. FISH results often inform therapeutic decisions and risk stratification in blood cancers.
Usage
Usage note: Always capitalize FISH when used as an acronym. The full form should be spelled out on first use.
In Context
- "FISH analysis revealed deletion 17p in 45% of the patient's CLL cells." — Laboratory report
- "The pathology report should specify which FISH probes were used in the analysis." — Editorial guidance