Intermediate
Technical
IVT
peripheral smear review
Manual microscopic examination of blood cells to assess morphology, distribution, and identify abnormal findings.
Full Definition
Peripheral smear review involves the manual microscopic examination of a thin layer of blood spread on a glass slide to evaluate cellular morphology, identify abnormal cells, and assess the accuracy of automated cell counts. This review is essential in hematologic oncology for detecting blast cells, atypical lymphocytes, schistocytes, and other morphologic abnormalities that automated analyzers might miss. The review includes assessment of red blood cell morphology, white blood cell differential, and platelet adequacy and morphology.
Usage
Usage note: Often abbreviated as 'smear review' in clinical documentation.
In Context
- "Peripheral smear review confirmed the presence of 15% blast cells in circulation." — Laboratory report
- "Manual peripheral smear review was requested due to automated analyzer flags." — Laboratory protocol
Also known as
blood smear examination
manual differential
Contrasted with
automated differential
Don't confuse with
bone marrow review
flow cytometry