R-CHOP
Pronunciation: are-chop
Also written as: R-CHOP — Rituximab-Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone
Standard chemotherapy regimen combining rituximab with CHOP for treating B-cell lymphomas. Cornerstone treatment protocol.
Full Definition
R-CHOP is a widely used chemotherapy regimen that combines rituximab (a monoclonal antibody) with the CHOP chemotherapy backbone consisting of cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin), and prednisone. This regimen revolutionized treatment of B-cell non-Hodgkin lymphomas, particularly diffuse large B-cell lymphoma, by adding targeted immunotherapy to conventional cytotoxic chemotherapy. R-CHOP is typically administered in 21-day cycles, and the addition of rituximab significantly improved cure rates compared to CHOP alone.
Usage
Usage note: Always hyphenate R-CHOP. Capitalize all letters in the acronym.
In Context
- "The patient completed six cycles of R-CHOP with excellent tolerance." — Treatment summary
- "R-CHOP remains the gold standard for frontline treatment of DLBCL." — Clinical guideline