HOMA-IR
Pronunciation: HO-ma I-R
Also written as: HOMA-IR — Homeostatic Model Assessment of Insulin Resistance
Homeostatic Model Assessment of Insulin Resistance, a calculated index used to assess insulin sensitivity.
Full Definition
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a mathematical model used to quantify insulin resistance from fasting glucose and insulin concentrations. The calculation provides an estimate of insulin sensitivity and beta-cell function, making it valuable for diagnosing metabolic disorders, particularly in PCOS and diabetes screening. The formula involves fasting insulin (μU/mL) multiplied by fasting glucose (mg/dL) divided by 405. Values above 2.5 generally indicate insulin resistance, though reference ranges may vary by laboratory and population. HOMA-IR is widely used in research and clinical practice as a cost-effective alternative to more complex insulin sensitivity tests.
Usage
Usage note: Always hyphenate; distinguish from HOMA-B (beta-cell function).
In Context
- "The patient's elevated HOMA-IR of 4.2 confirmed suspected insulin resistance." — Clinical laboratory report
- "HOMA-IR calculation requires both fasting glucose and insulin values from the same draw." — Laboratory procedure manual