Precision Profile
A comprehensive assessment of assay imprecision across the analytical measuring range, essential for hormone test validation.
Full Definition
A precision profile is a systematic evaluation of analytical imprecision (coefficient of variation) across the entire measuring range of a hormone assay, from the lower detection limit to the upper limit of quantification. This assessment typically involves multiple concentration levels with repeated measurements over several days to determine both within-run and between-run precision. For hormone testing, precision profiles are critical because they reveal where in the measuring range the assay performs optimally and identify concentration ranges where imprecision may compromise clinical interpretation. The precision profile helps establish the functional sensitivity (lowest concentration with acceptable precision, typically ≤20% CV) and guides clinical decision-making about result reliability at different hormone concentration levels.
In Context
- "The precision profile revealed optimal performance between 2-50 ng/mL for the testosterone assay." — Method validation report
- "Review the precision profile before establishing reference intervals for the new cortisol method." — Quality control procedure