Reference Interval
Laboratory-established normal ranges for hormone levels, typically representing 95% of healthy population values.
Full Definition
Reference intervals define the expected range of hormone concentrations in healthy individuals, typically calculated as the central 95% of values from a reference population. These intervals are crucial for interpreting hormone test results but can vary significantly between laboratories, analytical methods, and patient demographics. Age, sex, menstrual cycle phase, and time of day all influence hormone reference intervals. Clinical editors must recognize that reference intervals are guidelines rather than absolute diagnostic thresholds, and that laboratory-specific intervals should always be used when interpreting results.
Usage
Usage note: Preferred over 'normal range' in professional laboratory contexts.
In Context
- "The testosterone result fell within the laboratory's established reference interval for adult males." — Laboratory report interpretation
- "Reference intervals for pediatric populations require age-specific considerations." — Pediatric endocrine guidelines