Intermediate
Technical
IVT
Sex Hormone-Binding Globulin
A plasma protein that binds and transports sex hormones in the bloodstream.
Full Definition
Sex hormone-binding globulin (SHBG) is a glycoprotein synthesized in the liver that binds testosterone and estradiol with high affinity, regulating their bioavailability. SHBG levels are influenced by age, sex, thyroid status, insulin resistance, and liver function. Measurement of SHBG is essential for calculating free hormone concentrations and understanding the clinical significance of total hormone measurements, particularly in conditions affecting protein binding.
Usage
Usage note: Use hyphens when spelling out; abbreviate as 'SHBG' after first mention.
In Context
- "Elevated sex hormone-binding globulin levels may reduce bioavailable testosterone." — Hormone evaluation report
- "SHBG concentrations increase with age and hyperthyroidism." — Clinical interpretation guide
Also known as
SHBG
Testosterone-binding globulin
Don't confuse with
Albumin
Cortisol-binding globulin
Thyroid-binding globulin