MACE
Pronunciation: MAYS
Also written as: MACE — Major Adverse Cardiac Events
Major adverse cardiac events, a composite endpoint used in cardiovascular research including death, myocardial infarction, and repeat revascularization.
Full Definition
Major adverse cardiac events (MACE) represents a standardized composite endpoint widely employed in cardiovascular clinical trials and registries to assess treatment efficacy and safety. The traditional MACE definition typically includes cardiovascular death, myocardial infarction, and target vessel revascularization, though specific definitions may vary between studies. Some trials expand MACE to include stroke, creating a four-point MACE endpoint. This standardization allows comparison across different interventional cardiology studies and helps evaluate both short-term procedural success and long-term clinical outcomes. MACE rates serve as primary or secondary endpoints in most major cardiovascular device and pharmaceutical trials.
Usage
Usage note: Always define MACE components when first mentioned in clinical documents.
In Context
- "The study reported a 12% MACE rate at one-year follow-up." — Clinical trial publication
- "MACE endpoints were adjudicated by an independent clinical events committee." — Research methodology