target lesion revascularization
Also written as: TLR — Target Lesion Revascularization
A repeat intervention performed on the same coronary lesion previously treated with PCI.
Full Definition
Target lesion revascularization (TLR) refers to any repeat percutaneous or surgical intervention performed on the same coronary lesion that was previously treated with percutaneous coronary intervention. TLR is typically required due to restenosis, stent thrombosis, or disease progression at the treated site. This endpoint is commonly used in clinical trials and registries as a measure of procedural durability and long-term efficacy. TLR is distinguished from target vessel revascularization, which includes interventions anywhere within the same coronary vessel. The need for TLR represents a clinical failure of the initial intervention and often requires more complex repeat procedures.
Usage
Usage note: Hyphenate when used as compound modifier. TLR abbreviation standard in clinical research contexts.
In Context
- "The six-month follow-up revealed no need for target lesion revascularization in the drug-eluting stent group." — Clinical trial results
- "Target lesion revascularization was required due to focal in-stent restenosis at the proximal edge." — Repeat intervention report