HELLP syndrome
Pronunciation: HELP
Also written as: HELLP — Hemolysis, Elevated Liver enzymes, Low Platelets
A severe form of preeclampsia characterized by hemolysis, elevated liver enzymes, and low platelet count.
Full Definition
HELLP syndrome is a severe, life-threatening variant of preeclampsia characterized by a triad of clinical and laboratory findings: Hemolysis (destruction of red blood cells), Elevated Liver enzymes, and Low Platelet count. The syndrome typically develops in the third trimester but can occur postpartum. Patients may present with right upper quadrant pain, nausea, vomiting, and malaise, though some cases are asymptomatic until laboratory abnormalities are detected. HELLP syndrome requires immediate recognition and management, often necessitating prompt delivery regardless of gestational age. Complications include liver rupture, stroke, pulmonary edema, and disseminated intravascular coagulation.
Usage
Usage note: Use all capitals for the acronym. Pronunciation sounds like the word 'help.'
In Context
- "Laboratory results confirmed HELLP syndrome with hemolysis, AST of 156, and platelet count of 75,000." — Emergency consultation
- "The patient developed postpartum HELLP syndrome requiring intensive care unit monitoring." — Hospital discharge summary