choriocarcinoma
Pronunciation: KOR-ee-oh-kar-sin-OH-mah
A rare, aggressive malignant tumor arising from gestational trophoblastic tissue that can occur after pregnancy, miscarriage, or molar pregnancy.
Full Definition
Choriocarcinoma is a highly malignant form of gestational trophoblastic disease characterized by abnormal proliferation of syncytiotrophoblasts and cytotrophoblasts without chorionic villi formation. It typically develops following molar pregnancies, though it can also arise after normal pregnancies, miscarriages, or ectopic pregnancies. The tumor is known for its rapid growth and tendency to metastasize early, particularly to the lungs, liver, and brain. Despite its aggressive nature, choriocarcinoma is highly responsive to chemotherapy when detected early.
Usage
Usage note: Always specify 'gestational' when context is unclear to distinguish from non-gestational forms.
In Context
- "The patient's elevated β-hCG levels six months post-partum raised suspicion for choriocarcinoma." — Medical chart documentation
- "Following complete evacuation of the molar pregnancy, serial β-hCG monitoring is essential to detect potential choriocarcinoma development." — Clinical protocol