fetal fibronectin
Pronunciation: fee-tal FY-broh-NEK-tin
A protein marker tested in cervicovaginal secretions to assess preterm birth risk.
Full Definition
Fetal fibronectin (fFN) is a glycoprotein that acts as an adhesive between the chorion and decidua, normally absent from cervicovaginal secretions between 22 and 35 weeks gestation. Detection of fFN during this window indicates disruption of the maternal-fetal interface and significantly increases preterm birth risk. The test is particularly valuable for its high negative predictive value, meaning a negative result strongly suggests delivery will not occur within the next two weeks. This biomarker helps clinicians make informed decisions about interventions such as corticosteroid administration and maternal transport to facilities with neonatal intensive care capabilities.
Usage
Usage note: Often abbreviated as fFN in clinical documentation.
In Context
- "A positive fetal fibronectin test at 28 weeks prompted administration of antenatal corticosteroids." — High-risk pregnancy management note
- "The negative fetal fibronectin result provided reassurance that preterm delivery was unlikely within two weeks." — Emergency department assessment