Basal Cell Carcinoma
Pronunciation: BAY-zal sel kar-SIN-oh-mah
The most common form of skin cancer, arising from basal keratinocytes of the epidermis and characterised by slow growth and local invasion without distant metastasis in the majority of cases.
Full Definition
Basal cell carcinoma (BCC) is a malignant epithelial tumour derived from the basal layer of the epidermis or hair follicle outer root sheath. It is the most frequently diagnosed cancer worldwide and predominantly arises on sun-exposed skin of fair-complexioned individuals. Histological subtypes include nodular, superficial, morphoeic (sclerosing), and infiltrative, each with different clinical behavior and recurrence risk. BCC rarely metastasises but can cause significant local tissue destruction if untreated. Editors should ensure 'carcinoma' is not shortened to 'cancer' in pathology reports, and 'morphoeic' is spelled correctly (the variant 'morpheaform' is used in American English).
Usage
Usage note: Abbreviate to BCC after first use. British English uses 'morphoeic'; American English uses 'morpheaform'—editors should apply the appropriate regional variant consistently.
In Context
- "Histology confirmed a morphoeic basal cell carcinoma with positive deep margins following excision." — Histopathology report
- "Basal cell carcinoma at the nasal ala was referred for Mohs surgery given the high-risk site." — Dermatology referral letter